
PRIMARY HYPERPARATHRYOIDISM AND PREGNANCY PHPT is not common during pregnancy. Moderate or severe hypercalcemia during pregnancy may, however, expose the mother and the fetus to significant risks. Maternal complications of severe hypercalcemia include hyperemesis, nephrolithiasis or nephrocalcinosis, recurrent urinary tract infection, pancreatitis etc. Complications from the fetus include hypocalcemia and tetany, due to PTH suppression, preterm delivery, low birth weight etc. In interpreting the severity of hypercalcemia, the physician should keep in his/her mind that serum concentration of calcium declines with the evolution of pregnancy, mainly due to significant plasma volume expansion. For this reason, upper normal limit of calcium serum concentration is 9.5 mg/dL during pregnancy. In general, in most cases of asymptomatic or very mild PHPT during pregnancy observation is the preferred treatment option. However, surgery may be required in cases of severe hypercalcemia o...