EFFECTS OF SURGERY ON THE NATURAL HISTORY OF PRIMARY HYPERPARATHYROIDISM

Parathyroidectomy (PTx) is the only curative approach to primary hyperparathyroidism (PHPT). PTx removing all the hyperfunctioning parathyroid parenchyma achieves permanent cure of the disease and is associated with:

1.Significant improvement of bone mineral density (BMD)

2.Lower rate of bone (in particular, vertebral) fractures

3.Significant decrease of the risk for renal stone formation (especially, recurrent stones)

4.Prevention of decline in renal function among patients with chronic kidney disease

5.Ameliorates /eliminates vague clinical symptomatology, such as fatigue, sense of weakness, mild depression, memory impairment, cognitive dysfunction, musculoskeletal/joint pain, muscle weakness, hyperreflexia, etc. These vague symptoms are often underestimated before surgery.

These therapeutic results significantly improve quality of life following PTx.

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