REGIONAL NODAL
RECURRENCE OF DIFFERENTIATED THYROID CANCER– LIMITATIONS OF FNA
FNA
cytology and thyroglobulin (Tg) measurement in the aspirate could be used when
nodal involvement is suspected in patients with regional recurrence of differentiated
thyroid cancer. However, the clinician should keep in his/her mind the
following limitations of this approach:
1. FNA
cytology may be falsely negative in a significant percentage of patients (~ 25
%); therefore, FNA could be avoided when radiographic findings are highly
suggestive of malignancy
2. FNA may
be difficult or even impossible due to the specific location of the suspicious
lymph node.
3.Tg
measurement in the aspirate may be high (positive) with thyroid bed persistent
benign thyroid remnant tissue (if the patient has not been treated with RAI);
therefore, accurate sampling is required to avoid errors regarding
interpretation/evaluation of these results
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