MATERNAL COMPLICATIONS OF PRIMARY HYPERPARATHYROIDISM DURING PREGNANCY
Although primary hyperparathyroidism (PHPT) affects mainly women of older age groups, about 5 - 10 % of cases are diagnosed in women of childbearing age. The true prevalence of PHPT-associated complications during pregnancy is unknown. Maternal complications of PHPT during pregnancy include:
1.Nephrolithiasis
– the most common maternal complication
2.Pancreatitis-
incidence of about 10 %, ominous sign of disease severity during the 2nd
or 3rd trimester. Interestingly, its prevalence is higher than in PHPT
in non-pregnant women (1 %), a finding that indicates that it is favored by
pregnancy
3.Preeclampsia,
especially when PHPT is associated with vitamin D deficiency prior to delivery
4.Severe
hypercalcemia or parathyroid crisis – typically during the 3rd trimester
or in the post-partum period
5.Other
complications ranging from non-specific clinical manifestations to end-organ
calcification (e.g. cardiac arrythmias, osteopenia, peptic ulcer, renal
impairment etc)
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