HUNGRY BONE SYNDROME (HBS) FOLLOWING SUCCESSFUL PARATHYROIDECTOMY FOR PRIMARY HYPERPARATHYROIDISM (PHPT)

HBS following successful parathyroidectomy for PHPT is not uncommon occurring in about 10 – 15 % of patients. HBS is characterized by prolonged severe postoperative hypocalcemia  and hypophosphatemia. HBS is the result of accelerated remineralization of bone following sudden decreased of parathormone after successful parathyroidectomy. HBS requires aggressive management, often with intravenous calcium supplementation. HBS typically is associated with overt clinical manifestations of hypocalcemia, which may occasionally be dramatic (such as muscular spasms, including the ‘hand of the obstetrician’). The patient should be well informed about the possibility of HBS complicating postoperative course in order to recognize early clinical manifestations of this syndrome, enabling early and effective management.

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