FETAL COMPLICATIONS
OF MATERNAL PRIMARY HYPERPARATHYROIDISM (PHPT) DURING PREGNANCY
Maternal
PHPT during pregnancy is associated with significant fetal morbidity (up to 80
%). The most common and serious fetal complications include:
1.Neonatal
hypocalcemia and tetany (up to 50 %, with or without seizures), which may persist
for many weeks after birth and may require intravenous calcium supplementation.
Rarely, hypocalcemia may be permanent, due to parathyroid aplasia during
gestation
2.Stillbirth
3.Miscarriage
(x5), often during the 2nd trimester in women with calcium levels
> 11.5 mg/dL
4.Premature
birth
5.Intrauterine
growth retardation – low birth weight
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