THYROID CANCER AND GRAVES’ DISEASE

Thyroid cancer in patients with Graves’ disease was originally considered to be a rare coexistence (~ 2 %). Graves’ disease classically was considered in the past even as an ‘insurance against thyroid cancer’. However, thyroid nodules are frequently observed in patients with Graves’ disease (prevalence: 3-fold higher compared to the general population) and these nodules may be associated with a risk of thyroid cancer. Currently available data indicate the risk of thyroid cancer is at least double the widely-accepted ~ 2 %. Obviously, the diagnosis of thyroid cancer in Graves’ disease should be taken into consideration in selecting optimal management, since surgical treatment will be required in these cases.

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