DYNAMIC RISK STRATIFICATION IN MEDULLARY THYROID CANCER; PROGNOSTIC SIGNIFICANCE

Based on the response to therapy in individual patients, dynamic risk stratification of MTC includes the following clinical outcomes:

1.EXCELLENT RESPONSΕ

§  Undetectable calcitonin

§  Normal levels of CEA

§  Absence of structurally identifiable disease

2.BIOCHEMICAL INCOMPLETE RESPONSE

§  Detectable calcitonin or

§  Elevated CEA serum levels

§  Absence of structurally identifiable disease

3.STRUCTURAL INCOMPLETE RESPONSE

§  Presence of recurrent/persistent structurally identifiable disease

This dynamic risk stratification of patients with MTC has prognostic importance, since disease-specific mortality is < 3 %, 11 % and 40 – 55 % for patients with excellent response, biochemical incomplete response and structural incomplete response, respectively.

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